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Human FOLR1/Alpha Fr ELISA Kit PicoKine®

Human FOLR1/Alpha Fr ELISA Kit PicoKine®

Manufacturer	Boster
Category	Oncology Food Safety Allergenes Vitamines By Cell Type Carcinoma Sarcoma ELISA ELISA & Immunoassays ELISA Kits Immunoassay By Organ Brain Cancer Uterine, Ovarian & Cervical Cancer
Type	Elisa-Kit
Specific against	Human
Applications	ELISA
Amount	96 wells/kit, with removable strips.
Item no.	BOS-EK1242
Targets	FOLR2, FOLR1
eClass 6.1	32160605
eClass 9.0	32160605
Available
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Cell Type Markers, Tags & Cell Markers, Tumor Associated
Short Description	Human FOLR1/Alpha Fr ELISA Kit PicoKine® (96 Tests). Quantitate Human FOLR1 in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 10pg/ml.
Description	Human FOLR1/Alpha Fr ELISA Kit PicoKine® (96 Tests). Quantitate Human FOLR1 in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 10pg/ml.
Background	Folate receptor 1 adult is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family. It is mapped to 11q13.4. FOLR1 expression in Jurkat cells facilitated MBG or EBO entry, and FR-blocking reagents inhibited infection of MBG or EBO. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. The FOLR1 gene encodes the adult folate receptor, or folate-binding protein (FBP), which has a high affinity for folic acid and for several reduced folic acid derivatives, and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is also an important regulator of milk protein synthesis.
Gene Name	FOLR1
Application Details	Dilution ratio of 1:1, concentration in serum and plasma is 341-1240 pg/ml.
Immunogen	Expression system for standard: E.coli; Immunogen sequence: R25-S234
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk.
Capture antibody\|Detection antibody	monoclonal antibody from mouse\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin or EDTA
Gene Full Name	Folate receptor alpha
Molecular Weight	29819 MW
Protein Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation..
Subcellular Localization	Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane. Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Tissue Specificity	Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium..
Protein Name	Folate receptor alpha

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