Manufacturer |
Boster
|
Category |
|
Type |
Elisa-Kit |
Specific against |
Human |
Applications |
ELISA |
Amount |
96 wells/kit, with removable strips. |
Item no. |
BOS-EK1255 |
Targets |
CD320, CD209 |
eClass 6.1 |
32160605 |
eClass 9.0 |
32160605 |
Available |
|
Manufacturers Product Category |
PicoKine® ELISA Kits |
Manufacturers Research Category |
Adaptive Immunity, B Cells, Cell Biology, Cell Cycle, Cell Differentiation, Developmental Biology, Immunology, Organogenesis |
Short Description |
Human CD320 / 8D6A / TCblR ELISA Kit PicoKine® (96 Tests). Quantitate Human CD320 in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml. |
Description |
Human CD320 / 8D6A / TCblR ELISA Kit PicoKine® (96 Tests). Quantitate Human CD320 in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml. |
Background |
CD320 (cluster of differentiation 320), also known as 8D6A or TCBLR, is a human gene. It is mapped to chromosome 19p13.2. This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and the expression of CD320 enhanced B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. It has been found that antagonists of the CD320 signaling pathway may counter the growth of follicular lymphomas or other tumors that metastasize to lymphoid follicles. CD320 is also a specific receptor for uptake of TCN2-bound cobalamin. |
Gene Name |
CD320 |
Application Details |
Dilution ratio of 1:1, concentration in serum and plasma is 100-360 pg/ml. |
Immunogen |
Expression system for standard: NS0; Immunogen sequence: S36-Y229 |
Cross-reactivity |
There is no detectable cross-reactivity with other relevant proteins. |
Sample Type |
cell culture supernatants, serum, plasma (heparin, EDTA) and urine. |
Capture antibody|Detection antibody |
monoclonal antibody from mouse|polyclonal antibody from goat |
Storage |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
Anticoagulant |
heparin or EDTA |
Gene Full Name |
CD320 antigen |
Molecular Weight |
28991 MW |
Protein Function |
Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.. |
Subcellular Localization |
Membrane ; Single-pass type I membrane protein. |
Tissue Specificity |
Expressed abundantly on follicular dendritic cells (FDCs).. |
Protein Name |
CD320 antigen |
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