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Human FOLR2/Beta Fr ELISA Kit PicoKine®

Human FOLR2/Beta Fr ELISA Kit PicoKine®

Manufacturer	Boster
Category	Food Safety Vitamines ELISA ELISA & Immunoassays ELISA Kits Immunoassay
Type	Elisa-Kit
Specific against	Human
Applications	ELISA
Amount	96 wells/kit, with removable strips.
Item no.	BOS-EK1539
eClass 6.1	32160605
eClass 9.0	32160605
Available
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Cancer, Cofactors, Vitamins/Minerals, Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals
Short Description	Human FOLR2/Beta Fr ELISA Kit PicoKine® (96 Tests). Quantitate Human FOLR2 in cell culture supernatants and serum. Sensitivity: 1pg/ml.
Description	Human FOLR2/Beta Fr ELISA Kit PicoKine® (96 Tests). Quantitate Human FOLR2 in cell culture supernatants and serum. Sensitivity: 1pg/ml.
Background	Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.
Gene Name	FOLR2
Application Details	Dilution ratio of 1:5, concentration in serum is around 5.5 ng/ml.
Immunogen	Expression system for standard: NS0; Immunogen sequence: T17-N230
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants and serum.
Capture antibody\|Detection antibody	monoclonal antibody from mouse\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Gene Full Name	Folate receptor beta
Molecular Weight	29280 MW
Protein Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release..
Subcellular Localization	Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Tissue Specificity	Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues..
Protein Name	Folate receptor beta

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