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Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine®

Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine®

Manufacturer	Boster
Category	Oncology By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Sarcoma Cell Biology Cell Movement Cell Status ELISA Autophagy ELISA & Immunoassays ELISA Kits Immunoassay Cell Migration & Invasion By Organ Lung Cancer
Type	Elisa-Kit
Specific against	Mouse
Applications	ELISA
Amount	96 wells/kit, with removable strips.
Item no.	BOS-EK0449
Targets	RPTOR, PDGFB
eClass 6.1	32160605
eClass 9.0	32160605
Available
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Antiviral Signaling, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Macrophage/Inflammation
Short Description	Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl3 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml.
Description	Mouse MIP-1Alpha/CCL3 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl3 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml.
Background	Chemokine (C-C motif) ligand 3 (CCL3), so known as Macrophage inflammatory protein-1alpha (MIP-1 alpha), is a protein that in humans is encoded by the CCL3 gene. It is a cytokine which belongs to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes. This gene is mapped to 17q12. CCL3 plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. It has been found that the activation of CCR5 by CCL3 directly and independently activates a G-protein signaling pathway through GNAI2 and a tyrosine phosphorylation signaling pathway through JAK2.
Gene Name	CCL3
Application Details	Dilution ratio of 1:1, concentration in serum and plasma is around 50 pg/ml.
Immunogen	Expression system for standard: E.coli; Immunogen sequence: A24-A92
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, serum and plasma (heparin, EDTA, citrate).
Capture antibody\|Detection antibody	monoclonal antibody from rat\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin, EDTA or citrate
Gene Full Name	C-C motif chemokine 3
Molecular Weight	10345 MW
Protein Function	Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.
Subcellular Localization	Secreted.
Tissue Specificity	Expressed in lung, spleen, and pancreas.
Protein Name	C-C motif chemokine 3

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