Comparison

Mouse TREM-1 ELISA Kit PicoKine®

Manufacturer Boster
Category
Type Elisa-Kit
Specific against Mouse
Applications ELISA
Amount 96 wells/kit, with removable strips.
Item no. BOS-EK0845
Targets TREM2
eClass 6.1 32160605
eClass 9.0 32160605
Available
Manufacturers Product Category
PicoKine® ELISA Kits
Manufacturers Research Category
Immunology, Innate Immunity, Macrophage/Inflammation
Short Description
Mouse TREM-1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Trem1 in cell culture supernatants, serum, plasma (heparin, EDTA) and cell lysates. Sensitivity: 10pg/ml.
Description
Mouse TREM-1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Trem1 in cell culture supernatants, serum, plasma (heparin, EDTA) and cell lysates. Sensitivity: 10pg/ml.
Background
Trem1, Triggering receptor expressed on myeloid cells-1, is encoded by Trem1 gene. The expression of Trem1 is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. Trem1 is a 30-kD glycoprotein that is reduced to 26 kD by deglycosylation, in agreement with the predicted molecular mass. The Trem1 gene which contains 4 exons maps to chromosome 6p21.1, within a TREM gene cluster and the mouse Trem1 gene maps to chromosome 17 in a region that shows homology of synteny to human chromosome 6. The expression of Trem1 is upregulated by stimulation with lipopolysaccharide (LPS), gram-negative bacteria, and fungi. Cross-linking of Trem1 on neutrophils induces interleukin-8 (IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1 (MCP1, or SCYA2) and tumor necrosis factor (TNF); MCP1 and TNF secretion could be further upregulated by LPS-mediated priming. Trem1 engagement also induces upregulation of adhesion molecules (e.g., ITGB1) and costimulatory molecules (e.g., CD40). Trem1 is associated with DAP12 (TYROBP), a molecule frequently associated with activating receptors.
Gene Name
TREM1
Application Details
Dilution ratio of 1:1, concentration in serum and plasma is less than the lowest standard, 31.2 pg/ml.
Immunogen
Expression system for standard: NS0; Immunogen sequence: A21-S202
Cross-reactivity
There is no detectable cross-reactivity with other relevant proteins.
Sample Type
cell culture supernatants, serum, plasma (heparin, EDTA) and cell lysates.
Capture antibody|Detection antibody
monoclonal antibody from rat|polyclonal antibody from goat
Storage
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant
heparin or EDTA
Gene Full Name
Triggering receptor expressed on myeloid cells 1
Molecular Weight
25409 MW
Protein Function
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity)..
Subcellular Localization
Membrane ; Single-pass type I membrane protein.
Protein Name
Triggering receptor expressed on myeloid cells 1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 96 wells/kit, with removable strips.
Available: In stock
available

Delivery expected until 5/30/2024 

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?