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RAD17 Colorimetric Cell-Based ELISA Kit

RAD17 Colorimetric Cell-Based ELISA Kit

Item no.	BOS-EKC1492
Manufacturer	Boster
Amount	1 kit, containing one 96-well plate and all necessary reagents
Category	Oncology By Cell Type ELISA ELISA & Immunoassays ELISA Kits Immunoassay Immunostaining
Type	Elisa-Kit
Applications	ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Sensitivity	>5000 cells
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Cell cycle checkpoint protein RAD17,hRad17,RF-C/activator 1 homolog,RAD17,R24L
Available
Manufacturer - Category	Cell-Based ELISA Kits
Storage Conditions	Store at 4°C for up to 6 months.
Molecular Weight	77055 MW
Gene Name	RAD17
Gene Full Name	Cell cycle checkpoint protein RAD17
Protein Function	Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Subcellular Localization	Nucleus. Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Description	The RAD17 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor RAD17 protein expression profile in cells. The kit can be used for measuring the relative amounts of RAD17 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on RAD17.
Tissue Specificity	Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level).Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-EKC1492-datasheet.pdf

BOS-EKC1492-safety-datasheet.pdf