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SHP-2 Colorimetric Cell-Based ELISA Kit

SHP-2 Colorimetric Cell-Based ELISA Kit

Item no.	BOS-EKC1522
Manufacturer	Boster
Amount	1 kit, containing one 96-well plate and all necessary reagents
Category	Oncology By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Adenocarcinoma ELISA ELISA & Immunoassays ELISA Kits Immunoassay Immunostaining
Type	Elisa-Kit
Applications	ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Sensitivity	>5000 cells
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Tyrosine-protein phosphatase non-receptor type 11,3.1.3.48,Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3,PTPN11,PTP2C,SHPTP2
Available
Manufacturer - Category	Cell-Based ELISA Kits
Storage Conditions	Store at 4°C for up to 6 months.
Molecular Weight	68436 MW
Gene Name	PTPN11
Gene Full Name	Tyrosine-protein phosphatase non-receptor type 11
Protein Function	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
Subcellular Localization	Cytoplasm. Nucleus.
Description	The SHP-2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SHP-2 protein expression profile in cells. The kit can be used for measuring the relative amounts of SHP-2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SHP-2.
Tissue Specificity	Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-EKC1522-datasheet.pdf

BOS-EKC1522-safety-datasheet.pdf