MEF2A (Phospho-Ser408) Colorimetric Cell-Based ELISA Kit

Cell-Based ELISA Kits

54811 MW

Myocyte-specific enhancer factor 2A

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT] (4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

The MEF2A (Phospho-Ser408) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor MEF2A (Phospho-Ser408) protein expression profile in cells. The kit can be used for measuring the relative amounts of MEF2A (Phospho-Ser408) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on MEF2A (Phospho-Ser408).

Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined.