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SNAI1 (Phospho-Ser246) Colorimetric Cell-Based ELISA Kit

SNAI1 (Phospho-Ser246) Colorimetric Cell-Based ELISA Kit

Item no.	BOS-EKC2339
Manufacturer	Boster
Amount	1 kit, containing two 96-well plates and all necessary reagents
Category	Neuroscience Molecular Targets for Neuroscience ELISA ELISA & Immunoassays ELISA Kits Immunoassay Immunostaining
Type	Elisa-Kit
Applications	ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Sensitivity	>5000 cells
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Zinc finger protein SNAI1,Protein snail homolog 1,Protein sna,SNAI1,SNAH
Available
Manufacturer - Category	Cell-Based ELISA Kits
Storage Conditions	Store at 4°C for up to 6 months.
Molecular Weight	29083 MW
Gene Name	SNAI1
Gene Full Name	Zinc finger protein SNAI1
Protein Function	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Subcellular Localization	Nucleus. Cytoplasm. Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
Description	The SNAI1 (Phospho-Ser246) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SNAI1 (Phospho-Ser246) protein expression profile in cells. The kit can be used for measuring the relative amounts of SNAI1 (Phospho-Ser246) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SNAI1 (Phospho-Ser246).
Tissue Specificity	Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-EKC2339-datasheet.pdf

BOS-EKC2339-safety-datasheet.pdf