Vitamin D Receptor (Phospho-Ser208) Colorimetric Cell-Based ELISA Kit

Store at 4°C for up to 6 months.

VDR

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

The Vitamin D Receptor (Phospho-Ser208) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Vitamin D Receptor (Phospho-Ser208) protein expression profile in cells. The kit can be used for measuring the relative amounts of Vitamin D Receptor (Phospho-Ser208) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Vitamin D Receptor (Phospho-Ser208).