TARDBP (1-414) TAR DNA Binding Protein (1-414 a.a.) Human Recombinant Protein

Solution

TARDBP protein solution (0.25 mg/ml) containing 20mM Tris-HCl (pH 8.0), 0.1M NaCl, 1mM DTT, 1mM EDTA and 10% glycerol.

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.