Mouse B7-H2 Recombinant Protein

Recombinant Proteins

ICOSLG

Ion-exchange chromatography.

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.

Mouse B7-H2, also known as CD275, is expressed by antigen presenting cells, including B cells, monocytes/macrophages, and dendritic cells. It binds to the ICOS molecule. The interaction of ICOS/B7-H2 plays an important role in the T cell costimulation pathway. Mouse B7-H2 Recombinant Protein is purified B7-H2 produced in yeast.

Isoform 1 highest expression in lymphoid tissues, such as spleen (mostly in the marginal zone), lymph nodes (particularly in the cortex and in both primary and secondary follicles), thymus (predominantly in the medulla) and Peyer patches (mostly in the follicles), lower levels in many non- lymphoid tissues, such as brain, heart, kidney, liver, lung, skeletal muscle and testis. Present on freshly isolated splenic B- cells, T-cells, dendritic cells and macrophages. The expression of isoform 2 is restricted to heart, spleen and kidney.