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AT406 (Xevinapant, SM406, ARRY334543)

AT406 (Xevinapant, SM406, ARRY334543)

Item no.	V0053-5mg
Manufacturer	InvivoChem LLC
CASRN	1071992-99-8
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 2 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0053CAS #:1071992-99-8Purity >=98% Description: Xevinapant (formerly Debio1143; AT-406; SM-406, ARRY-334543) is a first-in-class and orally bioavailable peptidomimeticof SMAC (second mitochondrial-derived activator of caspases)/DIABLO with potential antitumor activity, also an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) proteins. It acts by binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Kis of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. Description:peptidomimeticof SMAC (second mitochondrial-derived activator of caspases) References: Cancer Res. 2004 Oct 15; 64(20):7183-90. References: Related CAS: 1071992-57-8 (HCl salt) 1071992-99-8 (free base)
Molecular Weight (MW)	561.71
Formula	C32H43N5O4
CAS No.	1071992-99-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (178.0 mM)
	Water: < 1 mg/mL (slightly soluble or insoluble)
	Ethanol: N/A
Solubility (In vivo)	30% Propylene glycol, 5% Tween 80, 65% D5W: 30mg/mL
Chemical Name/Synonym	AT-406; AT 406; AT406; SM-406, ARRY-334543; SM 406, ARRY 334543; SM406, ARRY334543; D 1143; Debio 1143; N65WC8PXDD; SM 406; (5S, 8S, 10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxo-decahydropyrrolo[1, 2-a][1, 5]diazocine-8-carboxamide;

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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