Tie2 kinase inhibitor

Description: Tie2 kinase inhibitor, optimized from SB-203580, is a reversible, selective and ATP-competitive Tie2 inhibitor with potential antitumor activity. It inhibits Tie2 with an IC50 of 0.25 uM. It is selective towards Tie2 with 200-fold selectivity over p38. Tie2 kinase inhibitor exhibited potent antitumor activity in a MOPC-315 plasmacytoma xenograft model.

References: Bioorg Med Chem Lett. 2007 Sep 1; 17(17):4756-60.

Synonym: Tie2-inhibitor-5; Tie2 IN 5; Tie2IN5; Tie2 kinase inhibitor 5; Tie2-IN-5; Tie2 inhibitor 5; Compound 5;

Chemical Name: 4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine

InChi Key: SINQIEAULQKUPD-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H, 1-2H3, (H, 28, 29)

SMILES Code: O=S(C1=CC=C(C2=NC(C3=CC=C4C=C(OC)C=CC4=C3)=C(C5=CC=NC=C5)N2)C=C1)C