Raloxifene HCl (LY-139481)

Description: Raloxifene HCl (also known as LY156758; LY-139481 HCl) is a selective estrogen antagonist or estrogen strogen receptor modulator (SERM), which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM. Raloxifene belongs to the benzothiophene class of estrogen strogen receptor modulator (SERM). Raloxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-ß-selective antagonist effect.

References: Drug Metab Dispos. 2004 Jan; 32(1):89-97; Endocrinology. 1996 May; 137(5):2075-84.

Related CAS #: 84449-90-1 (free base); 82640-04-8 or 84449-90-1 (HCl); 174264-50-7 (6-glucuronide); 84449-82-1 (dimethyl ester HCl); 185415-07-0 (4-Monomethyl Ether); 178451-13-3 (6-Monomethyl Ether); 84541-36-6 (Raloxifene Bismethyl Ether HCl, a metabolite of Raloxifene); 84541-38-8 (Raloxifene Bismethyl Ether); 182507-22-8 (Raloxifene 4'-glucuronide); 195454-31-0 (Raloxifene N-Oxide); 182507-20-6 (Raloxifene 6, 4'-Bis-beta-D-glucuronide); 174264-46-1 (4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene); 334758-18-8 (6-Raloxifene-beta-D-glucopyranoside); 334758-19-9 (4'-Raloxifene-beta-D-glucopyranoside); 174264-51-8 Methyl Raloxifene 4'-(2, 3, 4-Tri-O-acetyl-beta-D-glycopyranuronate); 1159977-58-8 7-4-(2-Piperidinyl)ethoxybenzoyl Raloxifene; 177744-96-6 (LY88074); 63676-25-5 (LY117018)