pf-02575799

InvivoChem Cat #:V2127CAS #:863491-70-7 Purity >=98%

Description: PF-02575799 is a novel and potent microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.77+/-0.29 nM. Based on preclinical efficacy and safety data and its potential for producing short-lived, weakly active metabolites, compound 13 (PF-02575799) advanced into phase 1 clinical studies.

References: Bioorg Med Chem Lett. 2011 Jul 15; 21(14):4150-4.

-20C for 3 years in powder form

Synonym: PF-02575799; PF 02575799; PF02575799.
Chemical Name: (S)-N-(2-((4-fluorobenzyl)(methyl)amino)-2-oxo-1-phenylethyl)-2-(4'-isopropoxy-[1, 1'-biphenyl]-2-carboxamido)quinoline-6-carboxamide
InChi Key: HMTLPJFACYNTHS-KDXMTYKHSA-N
InChi Code: InChI=1S/C42H37FN4O4/c1-27(2)51-34-21-15-29(16-22-34)35-11-7-8-12-36(35)41(49)45-38-24-18-31-25-32(17-23-37(31)44-38)40(48)46-39(30-9-5-4-6-10-30)42(50)47(3)26-28-13-19-33(43)20-14-28/h4-25, 27, 39H, 26H2, 1-3H3, (H, 46, 48)(H, 44, 45, 49)/t39-/m0/s1
SMILES Code: CC(C)Oc1ccc(cc1)c2ccccc2C(=O)Nc3ccc4cc(ccc4n3)C(=O)N[CH](c5ccccc5)C(=O)N(C)Cc6ccc(cc6)F