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KN-93 HCl

KN-93 HCl

Item no.	V2579-250mg
Manufacturer	InvivoChem LLC
CASRN	1956426-56-4
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2579CAS #:1956426-56-4Purity >=98% Description: KN-93 HCl is a potent, cell-permeable, reversible and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 uM, and with no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. KN-93 suppresses ventricular arrhythmia induced by LQT2 without decreasing TDR. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. KN-93 ameliorates levodopa-induced dyskinesia in a rat model of Parkinson's disease. KN-93 protects rat cerebral cortical neurons from N-methyl-D-aspartic acid-induced injury. Description: References: Biochem Biophys Res Commun. 1991 Dec 31; 181(3):968-75; Neuropsychiatr Dis Treat. 2013; 9:1213-20. References: Related CAS #: 1188890-41-6 (phosphate) 139298-40-1 (free base). 1188890-41-6 (phosphate) 139298-40-1 (free base).
Molecular Weight (MW)	537.5
Formula	C26H30Cl2N2O4S
CAS No.	1956426-56-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 31 mg/mL
	Water: N/A
	Ethanol: N/A
Other info	Chemical Name: N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride InChi Key: ATHMCQDBXQEIOK-IPZCTEOASA-N InChi Code: InChI=1S/C26H29ClN2O4S.ClH/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31, 32)25-15-13-24(33-2)14-16-25; /h3-16, 30H, 17-20H2, 1-2H3; 1H/b6-5+; SMILES Code: O=S(C1=CC=C(OC)C=C1)(N(C2=CC=CC=C2CN(C/C=C/C3=CC=C(Cl)C=C3)C)CCO)=O.[H]Cl
Synonyms	KN93; KN 93; KN-93; KN-93 HCl.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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