JI-101

Item no.	V2827-50mg
Manufacturer	InvivoChem LLC
CASRN	900573-88-8
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V2827CAS #:900573-88-8 Purity >=98% Description: JI-101 is an orally bioactive multi-kinase inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. JI-101 has shown potent in vitro and in vivo anticancer activity against a variety of cancer cell lines and xenografts. It is currently entering Phase II clinical development for the treatment of solid tumors. JI-101 is found to be stable in all preclinical and human liver microsomes. The % metabolized is ranged between 3.03-3.95 across the tested species liver microsomes.The % metabolized is relatively higher in mice liver microsomes followed by dog, human and rat liver microsomes. References: Arzneimittelforschung. 2012 Jan; 62(1):27-34
Molecular Weight (MW)	466.33
Formula	C??H??BrN?O?
CAS No.	900573-88-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES	O=C(NC1=CC(Br)=CC=C1OC)NC2=CC=CC3=C2C=CN3CC4=CC(N)=NC=C4
Synonyms	JI101, JI 101, JI-101

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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