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BIX01294 triHCl

BIX01294 triHCl

Item no.	V3451-50mg
Manufacturer	InvivoChem LLC
CASRN	1392399-03-9
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3451CAS #:1392399-03-9 (HCl salt)Purity >=98% Description: BIX01294 triHCl (the tri-hydrochloride salt of BIX01294) is a novel and potent inhibitor of G9a histone methyltransferase with IC50 of 2.7 uM in a cell-free assay. BIX-01294 was discovered by screening a library of 125, 000 synthetic and preselected compounds against G9a. BIX-01294 is selective for G9a and GLP (G9a-like protein) over several H3K9 PKMTs including SUV39H1 and ESET, other KMTs such as SET7/9, and the arginine methyltransferase PRTM1. The X-ray crystal structure of GLP and BIX-01294 confirmed that BIX-01294 bound to the histone peptide binding pocket but failed to interact with the lysine binding channel. References: Mol Cell. 2007 Feb 9; 25(3):473-81; J Biol Chem. 2010 May 28; 285(22):16538-45. Related CAS: 935693-62-2 (free base); 1392399-03-9 (triHCl salt) :
Molecular Weight (MW)	600.02
Formula	C28H38N6O2.3HCl
CAS No.	935693-62-2 (free base); 1392399-03-9 (HCl salt)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 98 mg/mL (163.3 mM)
	Water: > 10 mg/mL
	Ethanol: > 10 mg/mL (13.33 mM)
SMILES	CN1CCN(C2=NC(NC3CCN(CC4=CC=CC=C4)CC3)=C5C=C(OC)C(OC)=CC5=N2)CCC1.[H]Cl.[H]Cl.[H]Cl
Synonyms	BIX01294; BIX-01294; BIX 01294; N-(1-benzylpiperidin-4-yl)-6, 7-dimethoxy-2-(4-methyl-1, 4-diazepan-1-yl)quinazolin-4-amine trihydrochloride

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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