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canagliflozin-hemihydrate

canagliflozin-hemihydrate

Item no.	V3978-100mg
Manufacturer	InvivoChem LLC
CASRN	928672-86-0
Amount	100 mg
Quantity options	1 g 250 mg 2 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3978CAS #:928672-86-0 Purity >=98% Description: Canagliflozin (also known as TA 7284; JNJ 24831754ZAE; JNJ 28431754AAA; JNJ 28431754) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, it exhibits 413-fold selectivity over hSGLT1. Canagliflozin is a FDA approved drug for the treatment of type 2 diabetes. Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. Canagliflozin was approved by the FDA on March 29, 2013, and became the first SGLT2 inhibitor approved in the USA. References: PLoS One. 2012; 7(2):e30555; J Med Chem. 2010 Sep 9; 53(17):6355-60 Related CAS#: 928672-86-0 (hemihydrate); 842133-18-0 (free) Related CAS#: 928672-86-0 (hemihydrate); 842133-18-0 (free)
Molecular Weight (MW)	907.05
Formula	C48H52F2O11S2
CAS No.	928672-86-0 (hemihydrate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water: < 1 mg/mL
	Ethanol: > 100 mg/mL
Solubility (In vivo)	0.5% CMC+0.25% Tween 80: 18 mg/mL
Synonyms	JNJ 28431754 hemihydrate; JNJ 24831754; JNJ-24831754; JNJ24831754AAA hemihydrate; JNJ24831754ZAE; TA 7284; TA-7284 hemihydrate; TA7284;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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