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AZD7624

AZD7624

Item no.	V4240-50mg
Manufacturer	InvivoChem LLC
CASRN	1095004-78-6
Amount	50 mg
Quantity options	100 mg 10 mg 25 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4240CAS #:1095004-78-6 Purity >=98% Description: AZD7624 is a novel, potent and selective inhaled p38 inhibitor with anti-inflammatory activity. Inhaled drugs generally aim to drive a local pharmacological effect in lung, at the same time minimizing systemic exposure, in order to obtain efficacy in lung disease without unwanted systemic effects. AZD7624 can provide superior pharmacokinetic exposure and superior pharmacodynamic lung effects. In rats, inhaled AZD7624 had a five times higher dose-adjusted lung exposure compared with intravenous dosing. In healthy volunteers, lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNFalpha) in sputum has been shown to be significantly reduced (85%) by means of inhaled AZD7624. Description: References: J Pharmacol Exp Ther. 2018 Jun; 365(3):567-572. References:
	Name: AZD7624 CAS#: 1095004-78-6 Chemical Formula: C27H30FN5O3 Exact Mass: 491.2333 Molecular Weight: 491.5674 Elemental Analysis: C, 65.97; H, 6.15; F, 3.86; N, 14.25; O, 9.76
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: AZD-7624; AZD 7624; AZD7624; IUPAC/Chemical Name: N-cyclopropyl-3-fluoro-4-methyl-5-(3-((1-(2-(2-(methylamino)ethoxy)phenyl)cyclopropyl)amino)-2-oxopyrazin-1(2H)-yl)benzamide InChi Key: NNKPHNTWNILINE-UHFFFAOYSA-N InChi Code: InChI=1S/C27H30FN5O3/c1-17-21(28)15-18(25(34)31-19-7-8-19)16-22(17)33-13-11-30-24(26(33)35)32-27(9-10-27)20-5-3-4-6-23(20)36-14-12-29-2/h3-6, 11, 13, 15-16, 19, 29H, 7-10, 12, 14H2, 1-2H3, (H, 30, 32)(H, 31, 34) SMILES Code: O=C(NC1CC1)C2=CC(N3C(C(NC4(C5=CC=CC=C5OCCNC)CC4)=NC=C3)=O)=C(C)C(F)=C2

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Amount: 50 mg

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Delivery expected until 10/2/2025

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