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TARANABANT

TARANABANT

Item no.	V4367-50mg
Manufacturer	InvivoChem LLC
CASRN	701977-09-5
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4367CAS #:701977-09-5Purity >=98% Description: Taranabant (aslo known as MK-0364) is a novel, highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist being investigated as a potential treatment for obesity due to its anorectic effects. It inhibits the binding and functional activity of various agonists, with a binding Ki of 0.13 nM for the human CB1R in vitro. Taranabant reduces abdominal pain and increases intestinal transit in mice. It was discovered by Merck & Co. In October 2008, Merck discontinued the phase III clinical trials due to high level of central side effects, mainly depression and anxiety. References: J Med Chem. 2006 Dec 28; 49(26):7584-7; J Pharmacol Exp Ther. 2007 Jun; 321(3):1013-22. Related CAS#: 701977-00-6 (Taranabant racemate); 701977-08-4 Taranabant (1R, 2R)stereoisomer
	Name: Taranabant (MK-0364) CAS#: 701977-09-5 Chemical Formula: C27H25ClF3N3O2 Exact Mass: 515.1587 Molecular Weight: 515.96 Elemental Analysis: C, 62.85; H, 4.88; Cl, 6.87; F, 11.05; N, 8.14; O, 6.20
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: MK-0364; MK 0364; MK0364 IUPAC/Chemical Name: N-((2S, 3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide InChi Key: QLYKJCMUNUWAGO-GAJHUEQPSA-N InChi Code: InChI=1S/C27H25ClF3N3O2/c1-17(34-25(35)26(2, 3)36-24-12-9-21(16-33-24)27(29, 30)31)23(14-18-7-10-22(28)11-8-18)20-6-4-5-19(13-20)15-32/h4-13, 16-17, 23H, 14H2, 1-3H3, (H, 34, 35)/t17-, 23+/m0/s1 SMILES Code: CC(OC1=NC=C(C(F)(F)F)C=C1)(C)C(N[CH]([CH](C2=CC=CC(C#N)=C2)CC3=CC=C(Cl)C=C3)C)=O

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Amount: 50 mg

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Delivery expected until 10/2/2025

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