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ONO-AE3-208

ONO-AE3-208

Item no.	V4681-25mg
Manufacturer	InvivoChem LLC
CASRN	402473-54-5
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4681CAS #:402473-54-5Purity >=98% Description: ONO-AE3-208 is a novel and potent EP4 antagonist with Ki of 1.3 nM. ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer. The in vitro cell invasion and migration were suppressed by ONO-AE3-208 in a dose-dependent manner without affecting cell proliferation. The in vivo bone metastasis of PC3 was also suppressed by ONO-AE3-208 treatment. EP4 expression levels were correlated with prostate cancer cell invasiveness and EP4 specific antagonist ONO-AE3-208 suppressed cell invasion, migration, and bone metastasis, indicating that it is a potential novel therapeutic modality for the treatment of metastatic prostate cancer. References: Cell Biochem Biophys. 2014 Apr 18.
	Name: ONO-AE3-208 CAS#: 402473-54-5 Chemical Formula: C24H21FN2O3 Exact Mass: 404.1536 Molecular Weight: 404.4414 Elemental Analysis: C, 71.27; H, 5.23; F, 4.70; N, 6.93; O, 11.87
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: AE 3-208; AE-3-208; AE3-208; ONO AE3 208; ONO-AE3-208; ONO-AE-3-208; ONO-AE 3-208 IUPAC/Chemical Name: 4-cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]-benzenebutanoic acid InChi Key: MTDIMKNAJUQTIO-UHFFFAOYSA-N InChi Code: InChI=1S/C24H21FN2O3/c1-15(18-11-12-21(25)20-7-3-2-6-19(18)20)24(30)27-22-13-16(14-26)9-10-17(22)5-4-8-23(28)29/h2-3, 6-7, 9-13, 15H, 4-5, 8H2, 1H3, (H, 27, 30)(H, 28, 29) SMILES Code: O=C(O)CCCC1=CC=C(C#N)C=C1NC(C(C2=C3C=CC=CC3=C(F)C=C2)C)=O

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Amount: 25 mg

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Delivery expected until 9/4/2025

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