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Description: Cholecalciferol (Vitamin D3; Colecalciferol), a secosteroid (a steroid molecule with one ring open), is a naturally occuring form of vitamin D; Upon metabolic activation, cholecalciferol is converted to the active form, 1, 25-dihydroxy vitamin D3, which induces cell differentiation and prevents proliferation of cancer cells. Vitamin D3/Cholecalciferol is a steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1, 25-dihydroxycholecalciferol plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression.
References: Immunology. 2011 Oct; 134(2):123-39. doi: 10.1111/j.1365-2567.2011.03482.x.; Am J Kidney Dis. 2012 Jul; 60(1):139-56. doi: 10.1053/j.ajkd.2011.12.035.
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