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TNF-like 1 Recombinant Protein

TNF-like 1 Recombinant Protein

Item no.	PRS-91-029-0.05mg
Manufacturer	ProSci
Amount	0.05 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Neurodegeneration Markers
Type	Proteins Recombinant
Format	Lyophilized
Specific against	other
Conjugate/Tag	Tag Free
Purity	Greater than 95% as determined by reducing SDS-PAGE.<br />Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Sequence	Met1-Leu192
NCBI	TNFSF15
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Tumor Necrosis Factor Ligand Superfamily Member 15,TNF Ligand-Related Molecule 1,Vascular Endothelial Cell Growth Inhibitor,TNFSF15,TL1,VEGI
Shipping Condition	Room temperature
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Room Temp
Storage Conditions	Lyophilized protein should be stored at -20˚ C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7˚ C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚ C for 3 months.
Molecular Weight	21.86 kD
Biological Activity	ED50 is less than 5 μg/ml as determined by the dose-dependent inhibition of the proliferation of HUVEC cells.
Background	Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
By Type	Apoptosis, Chemokines & Cytokines, Immunology, Neuroscience
Protein Gi #	189047102
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM PB, 250mM NaCl, pH 7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Application Note	This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name	tumor necrosis factor superfamily member 15
NCBI Organism	Homo sapiens
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Manufacturer - Species	Human
By Species	Human

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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Delivery expected until 11/6/2025

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