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Timosaponin AIII

Timosaponin AIII

Item no.	TMO-T3395-500mg
Manufacturer	TargetMol
CASRN	41059-79-4
Amount	500 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,9961
Formula	C39H64O13
Smiles	C[C@@]12[C@@]3([C@](C[C@]1([C@]4([C@](CC2)([C@]5(C)[C@](CC4)(C[C@@H](O[C@H]6[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@@H](O)[C@@H](CO)O6)CC5)[H])[H])[H])[H])(O[C@@]8([C@H]3C)CC[C@H](C)CO8)[H])[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Filiferin B,AneMarsaponin A3,Timosaponin A3
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Cholinesterase (ChE)\|\|\|mTOR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	740.92
Description	Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
Pathways	Neuroscience\|\|\|PI3K/Akt/mTOR signaling
Bioactivity	Timosaponin AIII induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 Î¼M). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 Î¼M, BT474 cells; 6 Î¼M, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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