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SBI-553

SBI-553

Item no.	HY-125880-1mg
Manufacturer	MedChem Express
CASRN	1849603-72-0
Amount	1 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.73
Citations	[1]Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20.\|[2]Slosky LM, et al. β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. Cell. 2020 Jun 11;181(6):1364-1379.e14.
Smiles	CN(C1=CC2=C(N=C(N=C2C=C1)C3(CC3)F)N4CCC(CC4)C5=C(C=CC=C5)OC)CCO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Neurotensin Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	450.55
Product Description	SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1][2].
Manufacturer - Research Area	Endocrinology; Neurological Disease
Solubility	DMSO: 17 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	NTR1
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-125880-1mg-safety-datasheet.pdf