Retinoblastoma (Rb)

GWB-AE3F0D

LS174T cells. Normal colon and colon carcinoma

A synthetic peptide derived from C-terminal of human Retinoblastoma Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine but not on tyrosine residues. It forms a complex with SV40 large T antigen adenovirus E1A and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast colon prostate kidney nasopharynx and leukemia.