CD165 [SN2]

GWB-5E7243

IgG1

Human

CD165

0. 2 mg/ml Storage

For FACS: Use at an assay dependent dilution. For IHC-Fr: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Cellular

The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model the protein has at least 3 conformational states: pre-fusion native state pre-hairpin intermediate state and post-fusion hairpin state. During viral and target cell membrane fusion the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).

Transmembrane protein: Virion membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein (By similarity).

Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive precursor that is N-glycosylated and processed likely by host cell furin or by a furin-like protease in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R (By similarity).