UEV1 / CROC1 (221 aa isoform b)

GWB-2BF00E

Peptide with sequence AYKFRTHSPEALE-C from the N Terminus of the Notes: Western blot: Approx 27kDa band seen in K562 lysate. Recommended for use at 2-4ug/ml. Summary: The Kua-UEV mRNA is an infrequent but naturally occurring co-transcribed product of the neighboring Kua and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. Two alternative transcripts encoding different isoforms have been described. The proteins produced by these transcripts have UEV1 B domains but the proteins are localized to the cytoplasm rather than to the nucleus. The significance of these co-transcribed mRNAs and the function of their protein products have not yet been determined. [provided by RefSeq]. [1] Guo D. Han J. Adam B. L. Colburn N. H. Wang M. H. Dong Z. Eizirik D. L. She J. X. and Wang C. Y. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress[2] Dias D. C. Dolios G. Wang R. and Pan Z. Q. et al. CUL7: A DOC domain-containing cullin selectively binds Skp1. Fbx29 to form an SCF-like complex[3] Thomson T. M. Lozano J. J. Loukili N. Carrio R. Serras F. Cormand B. Valeri M. Diaz V. M. Abril J. Burset M. Merino J. et al. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua a newly identified gene[4] Long M. et al. A new function evolved from gene fusion[5] Deng L. Wang C. Spencer E. Yang L. Braun A. You J. Slaughter C. Pickart C. and Chen Z. J. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain