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8-Hydroxyguanine

8-Hydroxyguanine

Item no.	HY-113338-10mg
Manufacturer	MedChem Express
CASRN	5614-64-2
Amount	10 mg
Quantity options	10 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.37
Citations	[1]Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374(2):233-6.\|[2]Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel). 2023 Jun 19;12(6):1300.
Smiles	O=C1NC(N)=NC2=C1NC(N2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	8-Oxoguanine,8-oxo-Gua
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	167.13
Product Description	8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage[1][2].
Manufacturer - Research Area	Metabolic Disease
Solubility	1M NaOH : 25 mg/mL (ultrasonic; adjust pH to 12 with 1M NaOH)\|DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 4.72 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 60°C)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported
Isoform	Human Endogenous Metabolite

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HY-113338-10mg-safety-datasheet.pdf