GSK-A1

Item no.	HY-125118-10mM
Manufacturer	MedChem Express
CASRN	1416334-69-4
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.04
Citations	[1]Naveen Bojjireddy, et al. Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levels. J Biol Chem. 2014 Feb 28;289(9):6120-32.\|[2]Smulders L, et al. Phosphatidylinositol Monophosphates Regulate the Membrane Localization of HSPA1A, a Stress-Inducible 70-kDa Heat Shock Protein. Biomolecules. 2022 Jun 20;12(6):856. \|[3]Jiang X, et al. Targeting PI4KA sensitizes refractory leukemia to chemotherapy by modulating the ERK/AMPK/OXPHOS axis. Theranostics. 2022 Oct 3;12(16):6972-6988. \|[4]Li FL, et al. Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides. Nat Chem Biol. 2022 Oct;18(10):1076-1086.
Smiles	O=S(C1=CC(C2=CC=C3N=C(N)N(C4=CC=C(N5CCOCC5)C=C4)C3=C2)=CN=C1OC)(NC6=CC=CC=C6F)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	HCV; PI4K
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	574.63
Product Description	GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 inhibits PtdIns(4, 5)P2 resynthesis with an IC50 of about 3 nM. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4, 5)P2. GSK-A1 has the potential for anti-hepatitis C virus (HCV) research[1].
Manufacturer - Research Area	Infection
Solubility	DMSO: ≥ 2 mg/mL\|H2O: < 0.1 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; PI3K/Akt/mTOR
Isoform	PI4K; PI4KIIIα; PI4KIIIβ
Clinical information	No Development Reported

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HY-125118-10mM-safety-datasheet.pdf