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Anti-Apoptosis inhibitor 5/API5 Antibody Picoband®

Anti-Apoptosis inhibitor 5/API5 Antibody Picoband®

Item no.	BOS-PA1009
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Adhesion Molecules Antibodies By Cell Type Carcinoma Hematology Leukemia Myeloma Cell Biology Cell Culture Cytokines Immunohistochemistry Western Blot Immunocytochemistry Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Lung Cancer Bladder Cancer
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IF, IHC, ICC, IHC-F
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<10pg/ml
Citations	1. Hartz, P. A.Personal Communication.Baltimore, Md. 12/12/2005. 2. Tewari, M.; Yu, M.; Ross, B.; Dean, C.; Giordano, A.; Rubin, R. : AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. Cancer Res. 57: 4063-4069, 1997.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Apoptosis inhibitor 5;API-5;Antiapoptosis clone 11 protein;AAC-11;Cell migration-inducing gene 8 protein;Fibroblast growth factor 2-interacting factor;FIF;Protein XAGL;API5;MIG8;
Similar products	AAC 11 antibody, AAC-11 antibody, AAC11 antibody, Antiapoptosis clone 11 protein antibody, API 5 antibody, API-5 antibody, API5 antibody, API5 like 1 antibody, API5_HUMAN antibody, API5L1 antibody, Apoptosis inhibitor 5 antibody, Cell migration inducing gene 8 protein antibody, Cell migration-inducing gene 8 protein antibody, Fibroblast growth factor 2 interacting factor 2 antibody, Fibroblast growth factor 2-interacting factor antibody, FIF antibody, MIG 8 antibody, MIG8 antibody, Migration inducing protein MIG8 antibody, Protein XAGL antibody
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	59 kDa
Calculated Molecular weight	59005 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Human, Rat, Mouse Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, Mouse, Rat, By Heat Immunohistochemistry (Frozen Section), 0.5-1?g/ml, Rat, Human, Mouse Immunocytochemistry , 0.5-1?g/ml, Human, Mouse Immunocytochemistry/Immunofluorescence, 5 ?g/ml, Human
Manufacturer - Gene Name	API5
Gene Full Name	Apoptosis inhibitor 5
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Many growth factors and cytokines act as cellular survival factors by preventing programmed cell death (apoptosis). Apoptosis inhibitor 5 (API5) is an antiapoptotic factor which may have a role in protein assembly. The API5 gene to chromosome 11p12 based on an alignment of the API5 sequence with the genomic sequence It is a critical determinant of E2F1-induced apoptosis, acting downstream of E2F to suppress E2F-dependent apoptosis without generally blocking E2F-dependent transcription.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human Apoptosis inhibitor 5, different from the related mouse sequence by one amino acid.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Apoptosis, Cancer, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Receptors
Protein Name	Apoptosis inhibitor 5(API-5)
Protein Function	Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
Subcellular Localization	Nucleus. Cytoplasm. Mainly nuclear. Can also be cytoplasmic.
Description	Boster Bio Anti-Apoptosis inhibitor 5/API5 Antibody catalog # PA1009. Tested in IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
Sequence Similarities	Belongs to the API5 family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-PA1009-datasheet.pdf

BOS-PA1009-safety-datasheet.pdf