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Rabbit polyclonal antibody to human MANF (Mesencephalic astrocyte-derived neurotrophic factor)

Rabbit polyclonal antibody to human MANF (Mesencephalic astrocyte-derived neurotrophic factor)

Item no.	ICO-310-100
Manufacturer	Icosagen
Amount	100ug
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies
Type	Antibody Polyclonal
Applications	ELISA, Immunofluorescence, Western Blot, Immunohistochemistry
Specific against	other
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ARMET, ARP
Available
Background	MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson’s disease (Lindholm et al., 2008, Voutilainen et al., 2009). When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta
Buffer	Concentrated ammonium sulphate in PBS pH 7.4.
Clonality	Rabbit polyclonal
Immunogen	Human MANF
Immunogen Description	Recombinant human MANF protein produced using CHO-based Icosagen Cell factory Ltd. proprietary suspension cell line. Immunogen is purified from cell culture supernatant
Limitations	This product is for research use only
Protocol	ELISA 0.1 to 0.2 ug/ml; WB 0.15 to 0.5 ug/ml, IHC 10 ug/ml, IF 1 to 20 ug/ml No cross-reactivity in MANF-knockout mouse. No cross-reactivity with CDNF in IHC, slightly cross-reacts with purified CDNF in WB. Polyclonal antibody working titer has to be established practically for each particular antigen and assay format
Purification	MANF-affinity purified
References	-
Storage	Storage: Store at +4C upon receipt. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use
Uniprot ID	P55145

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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