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Granzyme B

Granzyme B

Item no.	RLT-M10-117S
Manufacturer	ReliaTech
Amount	2ug
Category	Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Mouse (Murine, Mus musculus)
Host	Insect Cells
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	Gzmb, GZB, CCP1, Ctla1, Ctla-1, AI553453, CCP-1/C11
Available
NCBI Gene ID	14939
Uniprot	P10144
Biological Activity	Determined by its ability to cleave a synthetic chromogentic Granzyme B substrate. The expected specific activity, when using the Ac-IEPD-pNA substrate at 250C, is greater than 750 nM/min per µg of enzyme.
Description	Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	227
Molecular Weight	28.9 kDa
mRNA RefSeq	NM_004131.4
Protein RefSeq	NP_004122.2
Protein Sequence	IIGGHEVKPH SRPYMALLSI KDQQPEAICG GFLIREDFVL TAAHCEGSII NVTLGAHNIK EQEKTQQVIP MVKCIPHPDY NPKTFSNDIM LLKLKSKAKR TRAVRPLNLP RRNVNVKPGD VCYVAGWGRM APMGKYSNTL QEVELTVQKD RECESYFKNR YNKTNQICAG DPKTKRASFR GDSGGPLVCK KVAAGIVSYG YKDGSPPRAF TKVSSFLSWI KKTMKSS
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	Gzmb; GZB; CCP1; Ctla1; Ctla-1; AI553453; CCP-1/C11
Uniprot ID	P10144

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 2ug

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Delivery expected until 10/16/2025

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