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5-O-Demethylnobiletin

5-O-Demethylnobiletin

Item no.	HY-N1942-5mg
Manufacturer	MedChem Express
CASRN	2174-59-6
Amount	5 mg
Quantity options	10 mg 1 mg 20 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.91
Citations	[1]Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42.\|[2]Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63.
Smiles	O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(O)=C13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	5-Demethylnobiletin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Leukotriene Receptor; Lipoxygenase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	388.37
Product Description	5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease; Cancer
Solubility	DMSO: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Metabolic Enzyme/Protease
Isoform	5-LOX; LTC4/CysLT2
Clinical information	No Development Reported

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HY-N1942-5mg-safety-datasheet.pdf