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EGFR-IN-2

EGFR-IN-2

Item no.	TMO-T11159-100mg
Manufacturer	TargetMol
CASRN	1643497-70-4
Amount	100 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Smiles	[C@@H](CC)(C)N1N=C(C=2C1=CC(NC3=NC(=NC=C3)C4=CN(S(=O)(=O)C5CC5)N=C4)=NC2)N6CC(C(C)(C)O)C6
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1643497-70-4
Shipping Condition	Cool pack
Available
Manufacturer - Targets	EGFR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	551.66
Description	EGFR-IN-2 is a non-covalent, orally available and mutation-selective EGFR inhibitor for the treatment of non-small cell lung cancer (NSCLC), with high selectivity for resistant single and double mutant T790M with IC50 = 27 nm to 33 nM, and low inhibitory activity for wild-type H292 (IC50 = 218 nM).
Pathways	Tyrosine Kinase/Adaptors\|\|\|JAK/STAT signaling\|\|\|Angiogenesis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

TMO-T11159-100mg-datasheet.pdf

TMO-T11159-100mg-safety-datasheet.pdf