Mouse Anti-Human CASP7 Clone B4-G2 mAb

Mouse Anti-multispecies Caspase 7 Clone B4-G2 monoclonal antibody. The caspase family of cysteine proteases plays a key role in apoptosis. Caspase 7is a 34 kDa protein that is activated during Fas- and TNF-induced apoptosis. Caspase 7 has been identified as a major contributor to the execution phase of cellular apoptosis. It cleaves essential cellular machinery following its own cleavage from an inactive proenzyme to an active heterodimeric form. Caspase 7 is processed by caspase 3, -6, -8, -9, and -10 as well as by Granzyme B.

Human, mouse, and rat. Detects both pro-caspase 7 (34 kDa) and the large subunit of cleaved caspase 7 (19 kDa) in apoptosis cells on SDS-PAGE immunoblots.