Rabbit Anti-Human GNA15 pAb

G-alpha 16 is the only hetero-trimeric G proteins with a restricted expression pattern in hematopoietic cells. Differentiation of promyelocytic cells leads to decreased expression of G-alpha 16. This G protein is known to couple a large number of G protein-coupled receptors to PLC-beta and can lead to production of the secondary messengers diacylglycerol and inositol phosphates. Targeted deletion of G-alpha 15, a mouse orthologue of human G-alpha 16, causes reduced C5a receptor signaling. G-alpha 16 serves as a marker, in addition to CD34, for hematopoietic progenitor cells.