Rabbit Anti-Human PAK1 pAb

4C for short term storage or -20C in small aliquots for long term storage. Avoid repeated freeze and thaw cycles.

This polyclonal antibody, which reacts with PAK1, was generated using, E. coli -expressed human PAK1 (a.a. 333-545) as an immunogen. Human p21-GTPase-activated protein kinase 1 (PAK1) is a functional homolog of STE20 of Saccharomyces cerevisiae. PAK1 is a downstream effector of the Rho-family small GTPases Rac and Cdc42. A serine/threonine kinase, PAK1 induces the formation of filopodia and lamellipodia in Swiss 3T3 cells. PAK1 inhibits myosin light chain kinase, and appears to play a role in the regulation of apoptosis by phosphorylating the death agonist Bad. Membrane targeting of PAK1 induces neurite outgrowth. PAK1 may also regulate NF-?B activation.

Reconstitute to 1 mg/ml by adding 200 ul PBS