Mouse Anti-Human TNF-alpha Clone MAb11 Biotin mAb

TNF-a is secreted by macrophages, monocytes, neutrophils, T-cells (principally CD4+), and NK-cells. Many transformed cell lines also secrete TNF-a. Monomeric human TNF-a is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kD. TNF-a forms multimeric complexes, stable trimers are most common in solution. A 26 kD membrane form of TNF-a has also been described. TNF-a binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines, in vitro , hemorraghic necrosis of tumors, in vivo , increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.

E. coli, -expressed, recombinant human TNF-a

0.5 mg/ml