Mouse Anti-Human Tau (pan) Clone TAU-5 mAb

Store at 2-4C. Store in working aliquots at -20C for longer storage. Avoid repeated freeze/thaw cycles.

Microtubule-Associated Protein Tau (MAPT) is a protein whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. Tau proteins promote the assembly of tubulin monomers into microtubules and stabilize microtubules. Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau. The TAU-5 monoclonal antibody reacts with the non-phosphorylated as well as the phosphorylated forms of tau. Its epitope is located in the middle region of tau. This antibody is highly specific for tau and does not cross-react with other microtubule associated proteins (MAPs) or tubulin. In immunohistology, this antibody intensely stains the human neurofibrillary tangles, neuropil threads, and neuritic plaques associated with Alzheimer’s disease. This antibody is also observed to stain astrocytes.

Purified Bovine microtubule-associated proteins.

Human, Sheep, Bovine, Mouse, and Rat Tau. This antibody recognizes proteins of 45-68 kDa, identified as Tau proteins.