Rabbit Anti-Human SHC1 Clone Poly6152 pAb

Shc (Src homology 2 containing protein) was originally identified as a protooncogene involved in growth factor signaling. A cytoplasmic protein, Shc becomes phosphorylated by tyrosine kinases involved in growth factor signaling, antigen receptor signaling, hormone receptor signaling, cytokine receptor signaling, G-coupled receptor signaling, and integrin signaling. Shc functions as an adaptor molecule in signal transduction pathways by virtue of its SH2, SH3, PTB domains. Three isoforms of Shc exist with apparent molecular weights of 46 kD, 52 kD, and 66 kD. Shc facilitates activation of Ras proteins in response to a variety of stimuli and can form stable complexes with receptor tyrosine kinases and receptors devoid of intrinsic kinase activity. Shc has been shown to interact with Grb2 and SOS, receptor tyrosine kinases associated with the receptors for EGF, PDGF, HGF, erbB-2, insulin, and the cytoplasmic tyrosine kinases Lck, Src, and Sea. The Poly6152 antibody recognizes the N-terminal region of human Shc and is useful for Western blot.

Recombinant (partial), N-terminal