Sheep Anti-Human Plasminogen pAb *di

Plasminogen (PLG) is a circulating zymogen that is converted to the active enzyme Plasmin by cleavage of the peptide bond between Arg-560 and Val-561, which is mediated by Urokinase (uPA/PLAU) and Tissue Plasminogen Activator (tPA/PLAT). The main function of Plasmin is to dissolve Fibrin blood clots. Plasmin, like Trypsin, belongs to the family of serine proteases Fibrin is a cofactor for Plasminogen activation by tPA. Urokinase Plasminogen Activator Receptor (uPAR) is a cofactor for Plasminogen activation by uPA. Plasmin is inactivated by Alpha-2-Antiplasmin, a serine protease inhibitor (serpin).

Affinity Purified by immobilized Human Plasminogen