Mouse Anti-Human CD59 (Clone MEM-43) mAb

Antibodies

The antibody is the prototypic antibody for the CD59 determinant, a PI-linked glycoprotein of 18-20 kD, which is broadly expressed on most types of of cells. The antigen is the major complement-protecting molecule of human cells. It is expressed on all leukocytes, erythrocytes and most other cell types. Binding of this antibody inhibits the complement-protecting activity of CD59. CD59 is one of the complement regulatory membrane proteins that is missing in Paroxysmal Nocturnal Haemoglobinuria (PNH). Anti CD59 reagents may therefore be useful in the differential diagnosis of PNH type II and PNH type I as reported (Sugita, Holguin).