Mouse Anti-Human Integrin alpha 2b/CD41 Clone CRC64 mAb

The monoclonal antibody recognizes the intact platelet GPIIb/IIIa complex (alphaIIb/beta3-integrin), i.e. it does not bind to dissociated GPIIb or GPIIIa. The antibody reacts with human platelets and megakaryocytes. Apparent molecular weight under reducing conditions: GPIIIa, 110 kD, GPIIb alpha chain, 125 kD, beta chain, 25 kD. The antibody does not bind to platelets from patients with Glanzmann thrombasthenia and does not recognize the vitronectin receptor, which contains GPIIIa as a beta subunit (cf. CD61). CRC64 (both intact antibody and F(ab')2 fragments) inhibits platelet aggregation by blocking fibrinogen binding to the glycoprotein IIb-IIIa complex.