Mouse Anti-Human HLA Class I Clone MEM-123 mAb

Antibodies

MAb MEM-123 was previously characterized as antibody recognizing HLA-A, -B and -C molecules. Recent studies detected that MAb MEM-123 also reacts with native HLA-G molecule expressed by cells transfected with full-length HLA-G cDNA. Cytofluorometric analysis showed that MAb MEM-123 does not block immunofluorescence staining of HLA-G transfectants by MEM-G/9 FITC conjugate. Mab MEM-123 reacts with all human classical MHC Class I molecules in native cell surface forms as well as with human HLA-G cDNA transfected cells. Mab MEM-123 completely blocks binding of standard pan MHC Mab W6/32 and does not block binding of Mab MEM-G/9 to surface-expressed HLA-G. Mab MEM-123 crossreacts with bovine MHC Class I molecules.