Mouse Anti-Human DAXX (CT) Clone DAXX-01 mAb

Antibodies

Daxx is a novel regulator/modulator of apoptosis implicated in Fas- and TGF-b-induced apoptotic pathways. It was also found to be associated with PML protein in discrete nuclear structures known as PML oncogenic domains (PODs). Daxx as predominantly nuclear protein also functions as a repressor of Pax3 and Ets1 induced transactivation. Interestingly, in association with ASK1 kinase Daxx translocates from nuclei to cytoplasm. Though Daxx is thought to be mainly proapoptotic protein, extensive embryonic apoptosis in Daxx-deficient mice as well as its anti-apoptotic role in CD43-induced apoptosis suggest a promiscuous function of Daxx in the regulation of apoptosis.