Rabbit Anti-Human CIDE-A (CT) Affinity Purified pAb

Apoptosis is related to many diseases and induced by a family of cell death receptors. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase DFF40/CAD, which is chaperoned and inhibited by DFF45/ICAD (1-4). DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified (5). CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD (5, 6). Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is expressed in many tissues. This polyclonal antibody can be used for detection of CIDE-A by Western blot at 1:1000 to 1:2000 dilution. Human brain tissue lysate can be used as positive control and an approximately 23 kDa band can be detected. It has no cross activity to CIDE-B. For research use only.