Rabbit Anti-Human BIM (IN) Affinity Purified pAb

Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1, 2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1, 2). This polyclonal antibody can be used for detection of Bim by Western blot at 1:1000 dilution. Human K562 cell lysate can be used as positive control and a 23 kDa band can be detected. This antibody is human, mouse, and rat reactive. This antibody is for research use only.